PhD in Novel Functions Epigenetic Cancer Driver Kmt2d PhD

At Aston University, tuition fees are 16,590 GBP per year.

The Kantidakis lab at Aston University offers a rigorous research environment for those looking to advance the boundaries of molecular oncology. This project focuses on KMT2D, a histone 3 lysine 4 (H3K4) methyltransferase that ranks among the top ten most mutated genes in human cancer genomes. While its role in chromatin modification is well-documented, the precise cellular functions of KMT2D remain largely elusive, particularly regarding its potential independent activity from its methyltransferase domain.

Candidates will join a team pioneering research into how KMT2D deficiency drives transcription stress and genomic instability. The project offers:

• Direct mentorship from the principal investigator in a research-active laboratory.
• Hands-on training in both standard and cutting-edge molecular and bioinformatic techniques, including RNA-Seq, chromatin assays, and immunofluorescence microscopy.
• Exposure to diverse experimental models, utilizing both immortalised mouse embryonic fibroblasts and human HCT116 colon cancer cell lines.

This PhD is ideal for highly motivated researchers eager to investigate the mechanistic links between transcriptional elongation, DNA damage, and the epigenetic landscape of cancer cells.

Aston University in Birmingham is a career-focused public research university with a central campus and a long tradition of linking education to industry. Founded from technical roots in 1895, Aston combines academic study with practical experience and is known for strong employability outcomes. The urban campus places students close to business, cultural and transport hubs, and a multicultural student community contributes to a friendly, supportive atmosphere.

Aston emphasises applied learning, professional placements and partnerships with employers, so many programmes integrate a placement year or live industry projects. Facilities include modern lecture spaces, specialised labs and student services that support academic success and wellbeing. Small-group teaching and strong student support ensure international students have access to language help, academic workshops and career guidance tailored to the UK labour market.

Student life blends campus convenience with Birmingham’s vibrant cultural scene, offering clubs, societies and volunteer opportunities to build networks and practical skills. The university’s careers team helps with CVs, internships and graduate recruitment, while accommodation and welfare services ease the transition to study in the UK. Applicants should explore course accreditation, placement options and scholarship possibilities early, and connect with Aston’s international advisers to plan applications and arrival logistics.